hrp0097t15 | Section | ESPE2023

Cognitive evaluation in children with 21 Hydroxylase Deficiency (21-OHD)

Moracas Cristina , Lorenzo Ivan , Apuzzo Diletta , Santamaria Fabiana , Amitrano Marianna , Salerno Mariacarolina , Capalbo Donatella

Objective: The balance between hypocortisolism and hyperandrogenism in patients with classic congenital adrenal hyperplasia (CAH) treated with lifelong glucocorticoid (GC) is challenging. Glucocorticoid receptors are widely expressed in the brain; therefore it has been hypothesized that alterations in the exposure to glucocorticoids may affect cognitive ability in individuals with CAH. Only few studies have addressed this issue in children and results are scan...